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    Mannitol Collagen Spheres

    Skin damage due to increasing exposure to blue light emitted by screens on our electronic devices is an increasing skin concern. Mannitol in our Mannitol Collagen Spheres protects against this blue light damage, preventing the skin from the fine lines and wrinkles, uneven skin tone and dehydrated skin. The peptides stimulate collagen synthesis.

    The Mannitol Collagen Spheres are lyophilized to maintain maximum efficiency and are easy to activate with our Activation Liquid 15 SF. Once activated the sphere turns into a serum that is easy to apply to the skin.

    The spheres are free from parabens, PEGs, colorants, silicones, fragrances and mineral oil and are suitable for all skin types. The Mannitol Collagen Spheres come in vials of 7 to suit your customers for daily fresh application.

    Read more about our unique mode of action and the active ingredients below…

    Application Video

    Skin Benefits
    • Protects against blue light damage
    • Boosts collagen synthesis and prevents the premature collagen degradation
    • Replenishes moisture depots
    Active Ingredients

    Mannitol

    Mannitol is a natural molecule which can be found in marine algae, in vegetables such as pumpkins, celery and strawberries, and in the exudate of shrubs and trees, such as the manna ash and olive tree.

    Mannitol has proven anti-oxidative properties and is demonstrated to protect from environmental stresses such as blue light or UV radiation. This anti-oxidative potential delays the degradation caused by radicals.

    Additionally, mannitol in known to act as humectant and moisturizer. Therefore it increases the moisture content of the skin and keeps it soft and smooth.1,2

    Soluble Collagen Molecules

    Soluble collagen molecules have an extremely high water-binding capacity which lead to increased hydration of the stratum corneum. The use of native collagen improves skin smoothness and gives the skin a pleasant feeling.3

    Peptides

    Peptides are short amino acid chains which mimic amino acids of the extracellular matrix. They stimulate targeted skin functions.
    Peptides stimulate the collagen synthesis and protect and support the skin’s stem cell renewal.4

    [1] Botta et al., Genotoxicity of visible light (400–800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens, J PhotochemPhotobiol B. 2008 Apr 25;91(1):24-34; P. André and F. Villain, Free-radical scavenging protperties of mannitol and ist role as a constituent of hyaluronic acid fillers: a literature review, Int J Cosmet Sci. 2017;39(4):355-360

    [2] André and Villain. Free Radical Scavenging Properties of Mannitol and Its Role as a Constituent of Hyaluronic Acid Fillers: A Literature Review Int J Cosmet Sci . 2017 Aug;39(4):355-360.

    [3] Datenblätter zum Einsatz von Wirkstoffen in kosmetischen Mitteln, Lebensmittelchemische Gesellschaft, AG Kosmetische Mittel, 2006

    [4] M. Alam, H. B. Gladstone and R.C. Tung, Cosmetic Dermatology, Elsevier, 2009

    Mode of Action

    Activation and Release

    Mannitol Collagen Spheres are activated with Activation Liquid 15SF and directly applied on the skin.

    Anti Blue Light Damage & Deep Moisturization

    Mannitol protects against blue light induced oxidative stress and infuses the skin with moisture, this prevents the damage and the hydration plumps the skin. The skin is kept intact which prevents from further damage.

    Intensive Moisturization

    High number of Soluble Native Collagen Molecules remain on skin’s surface and infuse the skin with moisture which reduces TEWL, smoothes lines and wrinkles and harmonizes skin tone.

    Stimulation of Collagen Synthesis & Cell Renewal

    Tetrapeptides are released into deeper skin layers that support skin’s stem cell renewal, increase elasticity of the skin and smooth and reduce lines and wrinkles.

    Significant Regenerating Results

    Protects against blue light damage and replenishes skin moisture to smooth lines and wrinkles.

    Clinical Efficacy

    Reduced Reactive Oxygen Species (ROS) from Blue Light

    Blue light induces ROS, which can damage DNA, lead to oxidative cell stress, collagen damage and reduction of collagen synthesis. By neutralizing ROS, Mannitol has superior anti-blue light damage properties.

    This study shows that the Mannitol Collagen Spheres significantly decreased ROS by over 50% compared to the untreated group.

    Botta et al. Genotoxicity of visible light (400.800 nm) and photoprotection assessment of ectoin, L-ergothioneine ad mannitol and four sunscreens. Journal of Photochemistry and Photobiology B: Biology 2008; 91: 24-34.

    Long Lasting Skin Moisture Effect

    This corneometer (skin hydration) test showed that the Mannitol Collagen Spheres had a positive and significant effect on skin hydration. Over 6 weeks the skin was 36% more hydrated.

    This shows a significant increase in skin moisture for a long lasting skin moisture effect and healthy skin.

    Dermatological Evaluation with Mannitol Collagen Sphere, Dermatest GmbH, Germany, 2019, n=20, activation with Activation Liquid 15SF, once daily use for 6 weeks, Corneometer measurement.

    Improved Skin Density – More Collagen

    This ultrasound analysis showed a qualitative increase of 28% in skin density.

    This shows that the Mannitol Collagen Spheres had a positive effect on skin density and collagen synthesis, the collagen is not destroyed and synthesis not slowed down by external influences like blue light.

    Additionally, collagen synthesis is increased resulting in more collagen.

    The skin is protected from premature aging caused by blue light and skin is regenerated!

    Dermatological Evaluation with Mannitol Collagen Sphere, Dermatest GmbH, Germany, 2019, n=20, activation with Activation Liquid 15SF, once daily use for 6 weeks, Ultrasound measurement

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